acclimatization  (Cell Signaling Technology Inc)

Journal: Journal of Speech, Language, and Hearing Research : JSLHR

Article Title: Reexamination of Data on the Acclimatization of Hearing Aid Benefit Using Experienced Hearing Aid Wearers as Controls

doi: 10.1044/2025_JSLHR-25-00563

Figure Lengend Snippet: Box plots of percent correct speech recognition scores for two unaided and three aided test conditions and for both new (New; gray) and experienced (Exp; white) hearing aid (HA) users. The circles at the top and bottom of each box plot represent the 95th and 5th percentiles, respectively. The solid lines within each box plot represent the medians, with the dashed lines representing the means. Results are presented separately for each of three different speech recognition measures from top to bottom. The heavy dashed horizontal line in each panel illustrates the study interval or potential acclimatization period from 1 to 12 months (mo) postfit. NST = Nonsense Syllable Test; CST = Connected Speech Test; SNR = signal-to-noise ratio.

Article Snippet: Of these three significant main effects of postfit interval, only the last one (CST in quiet) might be consistent with the expectations from auditory acclimatization, although even here the absence of a significant improvement from 1 to 6 months postfit is unexpected.

Techniques:

Journal: Journal of Speech, Language, and Hearing Research : JSLHR

Article Title: Reexamination of Data on the Acclimatization of Hearing Aid Benefit Using Experienced Hearing Aid Wearers as Controls

doi: 10.1044/2025_JSLHR-25-00563

Figure Lengend Snippet: Box plots of scores for the Hearing Handicap Inventory for the Elderly (HHIE) for one unaided and three aided test conditions and for both new (New; gray) and experienced (Exp; white) hearing aid (HA) users. The circles at the top and bottom of each box plot represent the 95th and 5th percentiles, respectively. The solid lines within each box plot represent the medians, with the dashed lines representing the means. The heavy dashed horizontal line in each panel illustrates the study interval or potential acclimatization period from 1 to 12 months (mo) postfit.

Article Snippet: Of these three significant main effects of postfit interval, only the last one (CST in quiet) might be consistent with the expectations from auditory acclimatization, although even here the absence of a significant improvement from 1 to 6 months postfit is unexpected.

Techniques:

Journal: Journal of Speech, Language, and Hearing Research : JSLHR

Article Title: Reexamination of Data on the Acclimatization of Hearing Aid Benefit Using Experienced Hearing Aid Wearers as Controls

doi: 10.1044/2025_JSLHR-25-00563

Figure Lengend Snippet: Box plots of scores for the Hearing Aid Performance Inventory (HAPI) for three aided test conditions and for both new (New; gray) and experienced (Exp; white) hearing aid users. Each panel presents the results for a separate subscale of the HAPI. The circles at the top and bottom of each box plot represent the 95th and 5th percentiles, respectively. The solid lines within each box plot represent the medians, with the dashed lines representing the means. The heavy dashed horizontal line in each panel illustrates the study interval or potential acclimatization period from 1 to 12 months (mo) postfit.

Article Snippet: Of these three significant main effects of postfit interval, only the last one (CST in quiet) might be consistent with the expectations from auditory acclimatization, although even here the absence of a significant improvement from 1 to 6 months postfit is unexpected.

Techniques:

Journal: Journal of Speech, Language, and Hearing Research : JSLHR

Article Title: Reexamination of Data on the Acclimatization of Hearing Aid Benefit Using Experienced Hearing Aid Wearers as Controls

doi: 10.1044/2025_JSLHR-25-00563

Figure Lengend Snippet: Box plots of scores for hearing aid usage, two left panels, and for hearing aid gain, two right panels at each of three postfit interval for both new (New; gray) and experienced (Exp; white) hearing aid users. The gain values shown are the bilateral average gain for frequencies of 1000, 2000, 3000, and 4000 Hz. The circles at the top and bottom of each box plot represent the 95th and 5th percentiles, respectively. The solid lines within each box plot represent the medians, with the dashed lines representing the means. The heavy dashed horizontal line in each panel illustrates the study interval or potential acclimatization period from 1 to 12 months (mo) postfit. HDABI = Hearing Disability and Aid Benefit Interview.

Article Snippet: Of these three significant main effects of postfit interval, only the last one (CST in quiet) might be consistent with the expectations from auditory acclimatization, although even here the absence of a significant improvement from 1 to 6 months postfit is unexpected.

Techniques:

Journal: NPJ Biofilms and Microbiomes

Article Title: Intermittent antibiotic exposure of Escherichia coli biofilms drives resistance in catheter-associated infection models

doi: 10.1038/s41522-025-00906-4

Figure Lengend Snippet: a Experimental protocol: Four cycles of 8-h intermittent amikacin lock therapy (ALT AMK ) at 500-fold MIC were performed on biofilms formed by the bioluminescent 55989 strain in TIVAPs, with a control group receiving PBS (ALT PBS ). Medical-grade 5 Fr TIVAPs were implanted in rats after a 1-week acclimatization. On day 4, the bioluminescent strain was inoculated into the TIVAP port. Biofilm formation was established over 3 days with daily TPN on days 5–8. The 8-h intermittent ALT and 16-h recovery phases were conducted from days 8–12, followed by a biofilm recovery phase with TPN on days 12–15. TIVAPs were collected from euthanized rats on day 15 for analysis. b Bioluminescence time course: Examples of bioluminescent imaging of biofilms treated with ALT AMK versus ALT PBS are presented (ALT PBS rat 3 and ALT AMK rat 4). c Endpoint TIVAP bioluminescence images: Extracted TIVAP images illustrating biofilm presence in each treatment group are shown. d Endpoint biofilm CFU: CFUs for biofilm samples were measured at the endpoint. e Growth frequencies on amikacin plates: Growth frequencies of biofilm cell samples on amikacin plates at 1 time the MIC are reported. f Amikacin MIC determination: The amikacin MIC values for biofilm cell samples grown on LB and MH media were assessed. g Whole-population genome sequencing (WGS)-based mutational analysis: Heatmaps showcasing mutations from endpoint biofilm populations, identified through WGS, are presented, with mutations at frequencies of ≥10% highlighted in orange (see Supplementary Data ). Biofilms were not recovered from the ALT AMK TIVAP 5 port and TIVAP 6 silicone and port (see Supplementary Fig. ). Si, Po, and Ca represent biofilm samples from the silicone septum, port, and catheter parts of each TIVAP, respectively. Means, individual values, and standard errors from three biological replicates (TIVAPs) are shown (Welch’s t -test, ** p < 0.001). Figure 4a was generated using BioRender.

Article Snippet: Briefly, after one week of acclimatization, TIVAP implantation surgery was performed for anesthetized 8-week male Crl:CD (SD) rats (Charles River, Wilmington, MA, USA) with isoflurane (ISO-VET, Piramal Critical Care, Bethlehem, PA, USA) on Day 0 as follows: the port part was implanted in the subcutaneous pocket on the back.

Techniques: Control, Imaging, Sequencing, Generated